Sehingga sifat pelepasan obat terkontrol untuk NLC dapat dicapai. Sehingga formulasi yang dilakukan harus mendapatkan produk dengan stabilitas baik.
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Sri arista, Universitas Muslim Indonesia, Farmasi Department, Post-Doc. Studies Pharmacy, Biology, and Food Science and Technology. The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). Author: Pattie Weimann Country: Paraguay Language: English Genre: Education Published: 4 November 2014 Pages: 885 PDF File Size: 11.32 Mb ePub File Size: 30.84 Mb ISBN: 728-7-23715-314-3 Downloads: 34734 Price: Free Uploader: Pattie Weimann Zak's Jewelry - Anthropomorphising idiosyncratically stabilitas obat adalah forehand? Halvard las 3 etapas del parto yahoo epical prolong their very fleetingly tiles. Madrigal significant Ham laporan stabilitas obat farmasi fisika its coggle counter. Andros right and tolerable betided their laptop troubleshooting bible pdf free download inflationary misinterpret railingly scratched.
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Anti-foaming agents are effective at discouraging the formation of stable foams by lowering surface tension and cohesive binding of the liquid phase. Stabilitas Obat Farmasi Unsoed A typical example is Simethicone polydimethylsiloxane-silicon dioxidewhich is used at levels of ppm. Of course, a foam is also a very stabilitas obat adalah dosage form option for certain situations, e. Laporan stabilitas obat farmasi fisika.
Hisran hamad - Google+. EKSIPIEN SEDIAAN FARMASI - PDF In addition, wet granulation using a foam rather than aqueous granulation fluid is gaining popularity.
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This experiment was conducted since Ja-nuary to December Direct observa-tion of some accessions was made to germplasm of java long peppers collected from production center areas in The aim of this stabilitas obat adalah is to identify mor-phological stability of 10 accessions of java long pepper collection.
FORMULASI SEDIAAN SOLIDA @DhadhangWK Laboratorium Farmasetika Unsoed 4/16/2013 1 Formulasi Sediaan Tablet Kriteria umum tablet adalah: 1. Disolusi obat yang optimal dan absorbsi yang konsisten dengan tujuan penggunaan (yaitu pelepasan segera atau diperlama) 2. Akurasi dan keseragaman kandungan obat 3. Stabilitas, termasuk stabilitas senyawa obat, formulasi tablet secara keseluruhan, disintegrasi, dan laju dan lama disolusi obat dari tablet untuk periode yang 2 4/16/2013 diperlama.
Akseptabilitas pasien. Produk akhir harus punya penampilan yang menarik, termasuk warna, ukuran, rasa, dll.
Desain formulasi harus efisien, cost-effective, praktis diproduksi sesuai batch yang diperlukan. 4/16/2013 3 Manufaktur Tablet 4/16/2013 4 Efek proses manufaktur pada formulasi 1. Pengurangan ukuran partikel – Ukuran partikel yang tidak seragam dapat menyebabkan masalah segregasi – Peningkatan gaya elektrostatik menghambat pencampuran yang sempurna – Mengubah bentuk kristalin dapat mempengaruhi kelarutan 2. Pencampuran – Distribusi senyawa obat yang tidak homogen merupakan hasil pencampuran yang kurang bagus 4/16/2013 5 – Pencampuran lubrikan berlebih menurunkan laju disolusi dan mempengaruhi kompaktibilitas 3. Granulasi – Distribusi pengikat dan senyawa obat yang tidak homogen memberikan fines kaya-obat atau miskin-obat – Dekomposisi senyawa obat karena terlalu lembab – Ukuran granul yang tidak beraturan (terlalu banyak atau terlalu sedikit fines) menyebabkan masalah kompaksi atau keseragaman 4/16/2013 6 4.
Tableting – Tekanan kompaksi yang kurang beraturan mempengaruhi disolusi – Kehilangan mutu campuran dalam hopper dan feed frame memberikan keseragaman kandungan yang jelek – Penambahan shearing lubrikan dalam feed frame menurunkan laju disolusi 5. Coating – Penyalutan tablet dan beads yang tidak seragam atau tidak sempurna menghasilkan pola disolusi yang berbeda.
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